27 Jan The New England Journal of MedicineNovember 18, 2004 – Volume 351 Number 21
Ultrasound-Enhanced Systemic Thrombolysis for Acute Ischemic Stroke: Transcranial Doppler ultrasonography that is aimed at residual obstructive intracranial blood flow may help expose thrombi to tissue plasminogen activator (t-PA). Our objective was to determine whether ultrasonography can safely enhance the thrombolytic activity of t-PA. In patients with acute ischemic stroke, continuous transcranial Doppler augments t-PA-induced arterial recanalization, with a nonsignificant trend toward an increased rate of recovery from stroke, as compared with placebo.
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